Filling perioral wrinkles with fat
Written and reviewed by Dr Bernard Hayot, ophthalmologist, RPPS 10003926226.

Filling perioral wrinkles with fat
In aesthetic medicine, two main approaches are used to treat them: the classic combination of botulinum toxin and hyaluronic acid, and a more recent approach based on the injection of fat and regenerative medicine products.
What causes perioral wrinkles?
Other factors also contribute to perioral wrinkles, among them sun exposure, smoking, stress, a poor diet and the repeated movements of the facial muscles involved in everyday expressions such as smiling, laughing and talking. Over time, these repeated movements crease the skin, and wrinkles form.
In addition, the loss of volume in the subcutaneous fatty tissue that occurs with age can accentuate the sagging of the skin around the mouth, and so contribute to perioral wrinkles.
The classic approach to treating perioral wrinkles combines botulinum toxin and hyaluronic acid. Botulinum toxin targets muscular overactivity, particularly of the orbicularis oris, which is often responsible for forming these wrinkles. Relaxing the muscle prevents new wrinkles from forming and reduces the appearance of existing ones, which also acts preventively against their deepening.
Hyaluronic acid is used to fill the wrinkles. Thanks to its capacity to retain water, it has an immediate volumising effect and smooths the perpendicular lines visible at rest on the red of the lips. A highly fluid hyaluronic acid is particularly suited to this delicate area, as it allows precise filling without over-correction or an artificial appearance.
How does filling perioral wrinkles with fat work?
The method begins by treating the wrinkles visible at rest with fat injected through extremely fine needles. This fat, taken from the patient themselves, is processed to obtain the fineness required for precise injection into delicate areas.
A nanofat treatment is then applied on top of the fat injection. Nanofat is rich in stem cells and growth factors, which not only fill the wrinkles but also significantly improve the quality of the skin. This regenerative approach aims to restore the skin from within, stimulating the production of new tissue and improving the elasticity and firmness of the skin around the lips.
Results of treating perioral wrinkles with fat
By targeting both the underlying cause of the wrinkles and the quality of the skin, it offers a lasting, natural solution for those seeking to reduce the appearance of wrinkles around the mouth. Unlike conventional methods, which focus mainly on filling and muscle relaxation, the regenerative approach treats the area as a whole and promises results that are both immediate and long-term.
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