Filling perioral wrinkles with fat

2025-04-112 min read

Written and reviewed by Dr Bernard Hayot, ophthalmologist, RPPS 10003926226.

Filling perioral wrinkles with fat

Filling perioral wrinkles with fat

The treatment of perioral wrinkles, the fine lines that appear around the mouth, is a common concern in aesthetic medicine. These wrinkles are often made worse by factors such as age, smoking, sun exposure and repeated facial expressions.

In aesthetic medicine, two main approaches are used to treat them: the classic combination of botulinum toxin and hyaluronic acid, and a more recent approach based on the injection of fat and regenerative medicine products.

What causes perioral wrinkles?

Perioral wrinkles, also known as smile lines or laugh lines, are mainly due to several factors, the first of which is the natural ageing process. With age, the production of collagen and elastin in the skin decreases, which leads to a loss of elasticity and firmness. The skin then becomes more prone to creasing and wrinkling, particularly around the mouth.

Other factors also contribute to perioral wrinkles, among them sun exposure, smoking, stress, a poor diet and the repeated movements of the facial muscles involved in everyday expressions such as smiling, laughing and talking. Over time, these repeated movements crease the skin, and wrinkles form.

In addition, the loss of volume in the subcutaneous fatty tissue that occurs with age can accentuate the sagging of the skin around the mouth, and so contribute to perioral wrinkles.

The classic approach to treating perioral wrinkles combines botulinum toxin and hyaluronic acid. Botulinum toxin targets muscular overactivity, particularly of the orbicularis oris, which is often responsible for forming these wrinkles. Relaxing the muscle prevents new wrinkles from forming and reduces the appearance of existing ones, which also acts preventively against their deepening.

Hyaluronic acid is used to fill the wrinkles. Thanks to its capacity to retain water, it has an immediate volumising effect and smooths the perpendicular lines visible at rest on the red of the lips. A highly fluid hyaluronic acid is particularly suited to this delicate area, as it allows precise filling without over-correction or an artificial appearance.

How does filling perioral wrinkles with fat work?

The innovative approach to treating perioral wrinkles is based on fat injection and on regenerative medicine products such as nanofat.

The method begins by treating the wrinkles visible at rest with fat injected through extremely fine needles. This fat, taken from the patient themselves, is processed to obtain the fineness required for precise injection into delicate areas.

A nanofat treatment is then applied on top of the fat injection. Nanofat is rich in stem cells and growth factors, which not only fill the wrinkles but also significantly improve the quality of the skin. This regenerative approach aims to restore the skin from within, stimulating the production of new tissue and improving the elasticity and firmness of the skin around the lips.

Results of treating perioral wrinkles with fat

The treatment of perioral wrinkles by fat injection, combined with regenerative medicine products such as nanofat, is a significant advance in facial aesthetic care.

By targeting both the underlying cause of the wrinkles and the quality of the skin, it offers a lasting, natural solution for those seeking to reduce the appearance of wrinkles around the mouth. Unlike conventional methods, which focus mainly on filling and muscle relaxation, the regenerative approach treats the area as a whole and promises results that are both immediate and long-term.

Our exchanges with web users

This page is for information. It does not replace a consultation: every situation is judged on examination.

Read more

The full text by Dr Hayot

The detailed version published on the site, kept in full. Each chapter unfolds.

Introduction
The treatment of perioral wrinkles, the fine lines that appear around the mouth, is a common concern in aesthetic medicine. These wrinkles are often made worse by factors such as age, smoking, sun exposure and repeated facial expressions. In aesthetic medicine, two main approaches are used to treat them: the classic combination of botulinum toxin and hyaluronic acid, and a more recent approach based on the injection of fat and regenerative medicine products.

What causes perioral wrinkles?

Perioral wrinkles, also known as smile lines or laugh lines, are mainly due to several factors, including the natural aging process. As we age, collagen and elastin production in the skin decreases, leading to a loss of elasticity and firmness. This loss of elasticity makes the skin more prone to creases and wrinkles, particularly around the mouth. Other factors can also contribute to the appearance of perioral wrinkles, including sun exposure, smoking, stress, poor diet, and repetitive movements of facial muscles, such as common facial expressions like smiling, laughing and talking. These repetitive movements can cause the skin to wrinkle over time, which can lead to the formation of wrinkles. In addition, the loss of volume in subcutaneous fatty tissue that occurs with age can also contribute to the appearance of perioral wrinkles, as it can accentuate the sagging of the skin around the mouth. The classic approach to treating perioral wrinkles combines the use of botulinum toxin and hyaluronic acid. Botulinum toxin targets muscular overactivity, particularly of the orbicularis oris, which is often responsible for forming these wrinkles. Relaxing the muscle prevents new wrinkles from forming and reduces the appearance of existing ones, which also acts preventively against their deepening. Hyaluronic acid is used to fill the wrinkles. Thanks to its capacity to retain water, it has an immediate volumising effect and smooths the perpendicular lines visible at rest on the red of the lips. A highly fluid hyaluronic acid is particularly suited to this delicate area, as it allows precise filling without over-correction or an artificial appearance.

How does filling perioral wrinkles with fat work?

The innovative approach to treating perioral wrinkles is based on fat injection and the use of regenerative medicine products such as nanofat. This method begins by treating existing wrinkles at rest with the injection of fat through extremely fine needles. This fat, taken from the patient himself, is processed to obtain the fineness required for precise injection into delicate areas. In addition to fat injection, a nanofat topping treatment is performed. Nanofat is rich in stem cells and growth factors, which not only fill in wrinkles but also significantly improve skin quality. This regenerative approach aims to restore the skin from within, stimulating the production of new tissue and improving the elasticity and firmness of the skin around the lips.

Results of treating perioral wrinkles with fat

The treatment of perioral wrinkles by fat injection, combined with the use of regenerative medicine products such as nanofat, represents a significant advance in facial aesthetic care. By targeting both the underlying cause of wrinkles and improving skin quality, this method offers a sustainable, natural solution for those seeking to reduce the appearance of wrinkles around the mouth. Unlike conventional methods, which focus mainly on filling and muscle relaxation, the regenerative approach treats the area as a whole and promises results that are both immediate and long-term.