Nano-lipofilling: fat injection

2025-04-112 min read

Before / after

Real cases from the practice, unretouched, framed on the treated area only. Each result is individual and does not predict yours.

BeforeBefore: Nanofat for pigmented dark circles, dark skin
AfterAfter: Nanofat for pigmented dark circles, dark skin
Nanofat for pigmented dark circles, dark skin
BeforeBefore: Pigmented dark circles treated with nanofat
AfterAfter: Pigmented dark circles treated with nanofat
Pigmented dark circles treated with nanofat

Written and reviewed by Dr Bernard Hayot, ophthalmologist, RPPS 10003926226.

Nano-lipofilling: fat injection

Nano-lipofilling, also known as nano-lipostructure or nanofat grafting, is a highly innovative and promising technique based on the injection of stem cells and growth factors into the dermis. Beyond a purely aesthetic effect, these cells can genuinely regenerate the tissues and so improve the texture, the quality and the radiance of the skin over the long term.

Nano-lipofilling is already giving results on skin quality, wrinkles and skin blemishes. It is also one of the effective treatments for masking the discolouration of dark circles.

What is nano-lipofilling?

Nano-lipofilling uses the patient’s own cells to regenerate ageing tissue.

Stem cells and growth factors are extracted and injected into the surface of the face. The fat is processed in the same way as for conventional lipofilling: it is filtered, defibrosed and broken down until it is highly fluid
This is genuinely regenerative medicine, not simply a new aesthetic method.

Technically, nano-lipofilling is similar to mesotherapy (injections into the superficial dermis), with one major difference: no foreign body or synthetic product is introduced into the patient’s body.

We have known for some years that lipofilling applied to the face does more than restore volume. The texture and the quality of the skin improve over the months. This positive effect is linked to the presence of stem cells and growth factors in the fat. That observation gave rise to regenerative medicine, which Dr Hayot sees as a major turning point in twenty-first-century aesthetic surgery.

Indications for nano-lipofilling in eye surgery

Nano-lipofilling is particularly indicated for countering the effects of skin ageing and eyelid sagging. It is also one of the effective solutions for treating dark circles.

Dark circles are caused by a thinning of the skin, which lets the blood vessels of the orbicularis muscle show through. Nano-lipofilling thickens the dermis and removes this transparency.

Dr Hayot strongly advises against injecting hyaluronic acid into the dark circles, as the results are unsatisfactory. Contrary to popular belief, hyaluronic acid does not resorb when placed in the dark circles: it swells and can cause bags to form.

Procedure for nano-lipofilling with Dr Hayot

At an initial consultation, Dr Hayot will examine you and check that you are a suitable candidate for nano-lipofilling. Your practitioner will explain the precautions to take before the procedure:

  • Obtain the prescribed medication in advance.
  • Stop taking anticoagulants and anti-inflammatory drugs.
  • Make an appointment with the anaesthetist to confirm that
  • the procedure is not contraindicated. A blood test should be carried out.
  • Fast for 8 hours before the procedure.

Nano-lipofilling is performed as a day case and lasts about an hour, usually under local anaesthetic.

Fat is removed from the abdomen, the thighs or the inner knees with a cannula. It is rinsed, cleaned, defibrosed and filtered. The resulting compound is then injected into the eyelids, so that the skin tissue can gradually regenerate.

Nano-lipofilling results

Nano-lipofilling delivers satisfying, long-lasting results.

The skin of the eyelids is gradually restored. It thickens and tightens as dark circles and wrinkles fade. An annual maintenance session may be recommended.

Side effects of nano-lipofilling

Some bruising and swelling may appear at the injection sites after the procedure. These signs are benign and disappear within a few days. Social downtime lasts 5 to 7 days.

Side effects are very rare. As this technique is a recent innovation, it is very important to consult a trained, competent surgeon with the appropriate equipment.

Fees for nano-lipofilling with Dr Hayot

The cost of the procedure depends on each patient’s indications and needs.

A personalised estimate will be provided at the end of the first consultation. It takes into account the fees of Dr Hayot, the anaesthetist and the hospital staff, as well as equipment costs and clinic fees.

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Introduction
Nano-lipofilling, also known as nano-lipostructure or nanofat grafting, is a highly innovative and promising technique based on the injection of stem cells and growth factors into the dermis. More than just an aesthetic effect, these cells can literally regenerate tissues, and thus sustainably improve skin texture, quality and radiance. Nano-lipofilling is already producing results in terms of skin quality, wrinkles and skin spots. It is also one of the effective treatments for masking the discolouration of dark circles.

What is nano-lipofilling?

Nano-lipofilling involves using a patient's own cells to regenerate ageing tissue. Stem cells and growth factors are extracted and injected into the surface of the face. This fat is treated in the same way as for conventional lipofilling: it is filtered, defibrosed and broken down to become highly fluid This is truly regenerative medicine, and not just a new aesthetic method. Technically, nano-lipofilling is similar to mesotherapy (injections into the superficial dermis), with one major difference: no foreign bodies or synthetic products are introduced into the patient's body. We've known for some years that lipofilling applied to the face has more than just a volume effect. Skin texture and quality improve over the months. This positive effect is linked to the presence of stem cells and growth factors in the fat. This observation has given rise to regenerative medicine, which Dr Hayot sees as a major turning point in 21st-century cosmetic surgery.

Indications for nano-lipofilling in eye surgery

Nano-lipofilling is particularly indicated for combating the effects of skin ageing and eyelid sagging. It is also one of the effective solutions for treating dark circles. Dark circles are caused by a thinning of the skin, which allows the blood vessels of the orbicularis muscle to show through. Nano-lipofilling thickens the dermis and eliminates this transparency. Dr Hayot strongly advises against the injection of hyaluronic acid into the dark circles, as the results are unsatisfactory. Contrary to popular belief, hyaluronic acid does not reabsorb when applied to the dark circles; rather, it swells and can cause bags to form.

Procedure for nano-lipofilling with Dr Hayot

At an initial consultation, Dr Hayot will examine you and check that you are a suitable candidate for nano-lipofilling. Your practitioner will explain the precautions to take before the procedure:
  • Obtain the prescribed medication in advance.
  • Stop taking anticoagulants and anti-inflammatory drugs.
  • Make an appointment with the anaesthetist to confirm that
  • the procedure is not contraindicated. A blood test should be carried out.
  • Fast for 8 hours before the procedure.
Nano-lipofilling takes place on an outpatient basis and lasts about an hour, usually under local anaesthetic. Using a cannula, fat is removed from the abdomen, thighs or inner knees. The fat is rinsed, cleaned, defibrosed and filtered. The resulting compound is then injected into the eyelids. The skin tissue can then gradually regenerate.

Nano-lipofilling results

Nano-lipofilling delivers satisfying, long-lasting results. The skin of the eyelids is gradually restored. It thickens and tightens as dark circles and wrinkles fade. An annual maintenance session may be recommended.

Side effects of nano-lipofilling

Some post-operative bruising and swelling may appear at the injection sites. These symptoms are benign and disappear within a few days. Social exclusion lasts 5 to 7 days. Side effects are very rare. As this technique is a recent innovation, it is very important to consult a trained, competent surgeon with the appropriate equipment.

Fees for nano-lipofilling with Dr Hayot

The cost of the procedure depends on each patient’s indications and needs. A personalised estimate will be provided at the end of the first consultation. It takes into account the fees of Dr Hayot, the anaesthetist and the hospital staff, as well as equipment costs and clinic fees.
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