How do you fill in deep wrinkles?
Written and reviewed by Dr Bernard Hayot, ophthalmologist, RPPS 10003926226.

What are wrinkles?
Wrinkles are folds or breaks in the skin that appear on the face over the years. Largely the result of skin ageing, they can begin to show as fine lines around the age of 25. These are generally expression lines, such as the frown lines between the eyebrows or the crow’s feet at the corners of the eyes. Then, as the years pass and lifestyles take their toll, the wrinkles deepen and settle permanently in the skin of the face, like the nasolabial folds, which gradually deepen.
What causes wrinkles to appear?
There are many causes for the appearance of wrinkles.
On the one hand, there are the internal causes, those that cannot be modified, such as genetics, skin type or ethnic origin, which influence the skin ageing process.
Then there are the so-called external causes, those that can be acted upon to delay the mechanisms of skin ageing and the appearance of wrinkles. These include tobacco and alcohol consumption, an unbalanced diet, stress, lack of sleep, insufficient skin hydration and exposure to UV rays.
How can deep wrinkles be filled in aesthetic medicine?
To treat deep wrinkles without surgery, there are several aesthetic medicine solutions.
Botox injection for wrinkles
Botulinum toxin injections are particularly suitable for treating expression lines, especially on the upper face. Botox is a product that prevents the repeated contraction of the muscles responsible for expression lines. It is therefore mainly used on the mobile areas of the face and neck, such as:
- Frown lines;
- Crow’s feet;
- Forehead wrinkles;
- Around the mouth;
- Chin and neck wrinkles.
This is not a permanent solution, however, and injections have to be repeated at regular intervals to maintain the effect.
Tensor threads to treat wrinkled skin
Absorbable tensor threads allow non-invasive facial rejuvenation. As well as acting on sagging skin tissue, tensor threads are effective in reducing the appearance of deep wrinkles in just half an hour, in the consulting room. The procedure also stimulates the natural production of collagen in the months that follow, giving patients a natural, gradual aesthetic result.
How can deep wrinkles be filled with cosmetic surgery?
When wrinkles are deeper, often at an older age, it is entirely possible to turn to cosmetic surgery to fill them. The first step, however, is hyaluronic acid injections, which can be used to treat nasolabial folds, cheek wrinkles, marionette lines and all breaks in the skin.
Anti-wrinkle fat injections (lipofilling)
Lipofilling consists of injections of autologous fat to treat all facial wrinkles, in particular:
- Frown lines;
- Crow’s feet;
- Wrinkles around the mouth;
- Nasolabial folds;
- Décolleté wrinkles.
Autologous fat, injected with extreme precision, fills wrinkles naturally for long-lasting results. As the fat comes from the patient’s own body, side effects are extremely rare.
Anti-wrinkle lipofilling can sometimes be combined with other techniques to rejuvenate the face overall, such as volumising lipofilling, blepharoplasty, filler injections or an oval and neck lift.
Nano-lipofilling for wrinkles
This technique involves injecting stem cells and growth factors to activate skin tissue regeneration. Nano-lipofilling naturally improves skin quality, particularly the appearance of deep wrinkles.
In lipostructure surgery, it is quite possible, in the operating room, to use the harvested fat for injections treating frown lines, nasolabial folds, wrinkles around the mouth and the décolleté.
This page is for information. It does not replace a consultation: every situation is judged on examination.